GLOSSARY

• Hereditary angioedema–is a rare disease caused by a deficiency or dysfunction of an important protein found in blood called C1 esterase inhibitor (C1-INH).
• Other names for hereditary angioedema:
  • Angioneurotic edema, hereditary
  • C1-INH
  • C1NH
  • Complement component 1 inhibitor deficiency
  • Complement component C1, regulatory component deficiency
  • Esterase inhibitor deficiency
  • HAE
  • HANE
• The 3 types of hereditary angioedema:

  Type I

  • Low levels of C1-INH in the body
  • C1-INH functions normally
  • Occurs equally in men and women
  • The most common: approximately 85% of people with HAE

  Type II

  • Normal levels of C1-INH
  • C1-INH does not function normally
  • Occurs equally in men and women
  • Approximately 15% of people with HAE

  HAE with normal functioning C1-INH (formerly known as type III HAE)

  • Normal level of C1-INH
  • C1-INH functions normally
  • Occurs more in women than men
  • Extremely rare

• Acute Treatment/Care–where a patient receives short-term treatment for a severe injury or episode of illness, an urgent medical condition, or during recovery from surgery. In medical terms, care for acute health conditions is the opposite from chronic care, or longer term care, and is also different from preventive or prophylactic care.
• Bradykinin–a kinin that is formed locally in injured tissue, acts in vasodilation of small arterioles, is considered to play a part in inflammatory processes, and is composed of a chain of 9 amino acid residues.
• C1-INH–C1-INH is a normal constituent of human plasma and has an important inhibiting potential on several of the major human cascade systems including the complement system. It inhibits C1, which is part of the complement system.
• Complement system–A group of nearly 60 proteins in blood plasma or on the surface of some cells. The complement proteins work with your immune system to protect the body from infections.
• Edema–A condition characterized by an excess of watery fluid collecting in the cavities or tissues of the body.
• Genetic condition–The inheritance of a changed gene that can increase risk of developing a particular condition.
• Hereditary–The passing on of physical or mental characteristics from one generation to another.
• Prophylaxis–Action taken to prevent a disease.
• Subcutaneous–Applied under the skin.
• Trigger–Cause an event or situation to happen or exist.